Antibacterial resistance (AR) is a natural phenomenon occurring when bacteria become insensitive to antibiotic treatments.

Tackling antibacterial resistance is one of the most ambitious challenges in XXI century, since it causes more than 700.000 deaths per year globally, doomed to increase up to 1 million by 2050 (https://www.who.int/drugresistance/documents/surveillancereport/en/).

To worsen the scenario, some bacteria may develop resistance against more than one antibiotic, becoming superbugs. The emergence of superbugs heralds a post-antibiotic era in which resistant infections will have a consistent impact not only on the health, but also on food security and on the economic output of our society.

The most resistant and worrisome superbugs are shortened in the acronym ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter). Up to date multiple preventive actions have been promoted to stem the spreading of resistant infections, however we still lack novel treatments to effectively counteract this microbiological menace.