Objectives
- Determination of the target druggability and first-round identification of ligands inhibiting the S.aureus hemophore-human Hb complex formation.
- Selection and optimization of potential antimicrobials able to iron-starve S. aureus and inhibit its growth in bloodstream.
- Identification and development of antimicrobials inhibiting heme scavenging in multiple Gram+.
- Validation of the ground-breaking nature of the methodology and consolidation of the platform.