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Objectives

  1.   Determination of the target druggability and first-round identification of ligands inhibiting the S.aureus hemophore-human Hb complex formation.
  2.   Selection and optimization of potential antimicrobials able to iron-starve S. aureus and inhibit its growth in bloodstream.
  3.   Identification and development of antimicrobials inhibiting heme scavenging in multiple Gram+.
  4.   Validation of the ground-breaking nature of the methodology and consolidation of the platform.